詹小平;秦金莹;曹高娟;李红芳;林祖金;
ZHAN Xiaoping;QIN Jinying;CAO Gaojuan;LI Hongfang;LIN Zujin;College of Life Sciences,Fujian Agriculture and Forestry University;State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences;

• 1:福建农林大学生命科学学院
• 2:中国科学院福建物质结构研究所结构化学国家重点实验

摘要(Abstract)：

细菌感染特别是多重耐药菌感染是当前临床治疗所面临的一大难题，加上细菌耐药问题越来越严峻，能用的有效药和治疗手段愈发局限。金属有机框架(metal-organic frameworks, MOFs)作为一种新型的多孔晶态材料，能释放自身抗菌组分、产生活性氧和负载抗菌剂，是当前最具潜力的抗菌材料，为克服细菌感染和耐药问题带了新的突破口。本文综述了MOFs的抗菌机理、抗菌应用和潜在的细胞毒性。总结了MOFs的金属离子、有机配体和氧化应激等主要抗菌机理，重点介绍不同结构的MOFs材料及其作为抗菌剂或抗菌载体在抗菌领域的应用，最后概述了MOFs可能存在的细胞毒性，提出MOFs抗菌应用仍需克服的一些困难，并展望了这类抗菌材料今后的发展方向。
Bacterial infections, especially multi-drug resistant bacterial infections, are one of the major problems in current clinical treatments. What is more, bacterial resistance is also becoming more and more serious, leading to the limited availability of effective drugs and treatment methods. As a new type of porous crystalline material, metal-organic frameworks(MOFs) represent promising materials to deal with the above problems; they can serve as effective antibacterial agents by releasing their own antibacterial components, producing reactive oxygen species, and loading antibacterial agents. Herein, we review the antibacterial mechanism, antibacterial applications, and potential cytotoxicity of MOFs. First, we summarize the main antibacterial mechanisms of MOFs, including the release of metal ions and organic ligands and induction of oxidative stress. Then, we emphatically introduce MOF materials used as antibacterial agents or solid carriers for loading antibacterial agents for use in the antibacterial field. Finally, we summarize the potential cytotoxicity of MOFs, point out the current challenges that need to be solved, and prospect the future development of MOF-based antibacterial agents.

关键词(KeyWords)： 多重耐药菌;金属有机框架;抗菌机理;抗菌应用;细胞毒性
multi-drug resistant bacteria;metal-organic framework;antibacterial mechanism;antibacterial applications;cytotoxicity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(22171265);; 福建省自然科学基金(2020J01549);; 福建农林大学项目(CXZX2020042A,118360020,XJQ201616)

作者(Authors): 詹小平;秦金莹;曹高娟;李红芳;林祖金;
ZHAN Xiaoping;QIN Jinying;CAO Gaojuan;LI Hongfang;LIN Zujin;College of Life Sciences,Fujian Agriculture and Forestry University;State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences;

DOI: 10.15914/j.cnki.wykx.2022.02.01

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